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		Scientific Papers of R.F. Marsh http://mad-cow.org Long List of TSE Researchers with their Contact info http://mad-cow.org A Career In Microbiology Can Be Harmful To Your Health - Death Toll Mounting.... From The Wilderness Publications - 03/03/02 Protein folding and disease - Session highlights Drug Discovery@Nature.com - 11/12/02 Dynamics of Gray Matter Loss in Alzheimer's Disease The Journal of Neuroscience, Feb. 1, 2003, 23(3):994 - Full Text PDF - Videos & more... Prion protein NMR structures of elk and of mouse/elk hybrids PNAS \| January 18, 2005 \| vol. 102 \| no. 3 \| 646-650 - full text Sexual Segregation in Ruminants: Definitions, Hypotheses, and Implications for Conservation and Management Journal of Mammalogy - 01/08/05 Chronic Wasting Disease and Potential Transmission to Humans Centers for Disease Control - June 2004 Re: Chronic Wasting Disease and Potential Transmission to Humans Terry S. Singeltary Sr. - 04/08/04 Decontamination of surgical instruments from prion proteins: in vitro studies on the detachment, destabilization and degradation of PrPSc bound to steel surfaces Journal of General Virology - December 2004; Vol. 85, No. 12 Transmission of Prions from Mule Deer and Elk with Chronic Wasting Disease to Transgenic Mice Expressing Cervid PrP Journal of Virology, December 2004, p. 13345-13350, Vol. 78, No. 23 - Full Text Identification of central nervous system genes involved in the host response to the scrapie agent during preclinical and clinical infection J Gen Virol 2004 85: 3459-3471 Abnormal prion protein in genetically resistant sheep from a scrapie-infected flock J Gen Virol 2004 85: 3483-3486 Identification of putative atypical scrapie in sheep in Portugal J Gen Virol 85 (2004), 3487-3491 The first Canadian indigenous case of bovine spongiform encephalopathy (BSE) has molecular characteristics for prion protein that are similar to those of BSE in the United Kingdom but differ from those of chronic wasting disease in captive elk and deer Can Vet J 2004;45:825–830 A protein-binding ligand system for prion disease detection Medical Device Link - 10/08/04 Experimental Transmission of Chronic Wasting Disease Agent to Cattle by Intracerebral Route: Final Outcome of the Study USDA Agricultural Research Service Experimental Inoculation of Tme, Scrapie, and Cwd to Raccoons: An Update USDA Agricultural Research Service Experimental Cross-Species Transmission of Chronic Wasting Disease (Cwd) at the National Animal Disease Center (Nadc), Ames, Iowa: An Update USDA Agricultural Research Service A PRELIMINARY REPORT ON HUNTER EFFORT AND ATTITUDES IN WISCONSIN’S CHRONIC WASTING DISEASE ERADICATION ZONE: RESULTS FROM THE 2OO3 EXTENDED DEER SEASON Robert H. Holsman & Ryan D. Meinerz, College of Natural Resources, UW-Stevens Point - August 2004 (pdf) Human Dimensions of Wildlife - Special CWD Issue $7.00 order today! (pdf) Table of Contents Fire in the Sistine Chapel: How Wisconsin Responded to Chronic Wasting Disease Human Dimensions of Wildlife, 9:165–179, 2004 - Full Text The Economic Impacts of Chronic Wasting Disease (CWD) in Wisconsin Human Dimensions of Wildlife, 9:181 -192, 2004 - Full Text Variable patterns of distribution of PrPCWD in the obex and cranial lymphoid tissues of Rocky Mountain elk (Cervus elaphus nelsoni) with subclinical chronic wasting disease The Veterinary Record - Volume 155, No. 10 Consumption of uncooked deer meat as a risk factor for hepatitis E virus infection: An age- and sex-matched case-control study Journal of Medical Virology - Volume 74, Issue 1, Pages 67 - 70 (abstract) Transmission of sheep scrapie to elk by intracerebral inoculation: final outcome of the experiment Journal Of Veterinary Diagnostic Investigation Transfusion transmission of vCJD: a crisis avoided? [FULL TEXT] The Lancet - Volume 364, Number 9433 07 August 2004 Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient [FULL TEXT] The Lancet - Volume 364, Number 9433 07 August 2004 Novel methods for disinfection of prion-contaminated medical devices [FULL TEXT] The Lancet - Volume 364, Number 9433 07 August 2004 Effectiveness of leucoreduction for removal of infectivity of transmissible spongiform encephalopathies from blood [FULL TEXT] The Lancet - Volume 364, Number 9433 07 August 2004 Immunological detection of prions U.S. Patent # 6,765,088 Government confirms second case of vCJD transmitted by blood transfusion / Obstacles to conducting epidemiological research in the UK general population BMJ 2004;329:251 - BMJ 2004;329:277-279 Scrapie transmission following exposure through the skin is dependent on follicular dendritic cells in lymphoid tissues Journal of Dermatological Science - Vol 35, Issue 2 , August 2004 - Full Text Progress and problems in the biology, diagnostics, and therapeutics of prion diseases J. Clin. Invest. 114:153-160 (2004) Prion protein codon 129 polymorphism and risk of Alzheimer disease NEUROLOGY 2004;63:364-366 - Full Text Presentation of a case of variant CJD in general dental practice [FULL TEXT] Br Dent J. 2004 Jul 24 Role of Interleukin-1 in Prion Disease-Associated Astrocyte Activation American Journal of Pathology. 2004;165:671-678 Characterization of two distinct prion strains derived from bovine spongiform encephalopathy transmissions to inbred mice Journal of General Virology - 85 (2004), 2471-2478 - Full Text Evaluation of new cell culture inhibitors of protease-resistant prion protein against scrapie infection in mice Journal of General Virology - 85 (2004), 2479-2483 Bovine Spongiform Encephalopathy Infectivity in Greater Kudu (Tragelaphus strepsiceros) Emerging Infectious Diseases Researchers find CWD more prevalent in older bucks - Disease is also not uniformly distributed within infected area Wisconsin Department of Natural Resources - 07/01/04 Mad cow-like diseases linked by bacteria United Press International - 06/25/04 - CJD Diagnostic & Research Center - Neuropathology of spiroplasma infection in the rat brain - Dangerous Liaisons between a Microbe and the Prion Protein - Cellular Prion Protein Promotes Brucella Infection into Macrophages Linking chronic wasting disease to scrapie by comparison of Spiroplasma mirum ribosomal DNA sequences Exp Mol Pathol. 2004 Aug;77(1):49-56 - Full Text Chronic wasting disease in Canada: Part 1 Can Vet J 2004;45:397-404 Environmental Sources of Prion Transmission in Mule Deer Emerging Infectious Diseases - Vol 10, No 6 - June 2004 Biotic Impoverishment and Homogenization in Unfragmented Forest Understory Communities Conservation Biology - Volume 18 Issue 3 Page 787 - June 2004 (abstract) PrPSc accumulation in myocytes from sheep incubating natural scrapie Nature Medicine - 23 May 2004 (pdf) - Supplementary Information (pdf) Preclinical deposition of pathological prion protein PrPSc in muscles of hamsters orally exposed to scrapie The Journal of Clinical Investigation Volume 113 Number 10 May 2004 (pdf) Polymorphisms in the prion precursor functional gene but not the pseudogene are associated with susceptibility to chronic wasting disease in white-tailed deer Journal of General Virology - 2004 85: 1339-1346 EPA Region 8 \| Recommended Best Management Practices for Disposal of Laboratory Waste Potentially Contaminated with Chronic Wasting Disease Environmental Protection Agency Chronic Wasting Disease—Prion Disease in the Wild April 2004 \| Volume 2 \| Issue 4 \| Page 0427 - more with Terry S. Singeltary Sr. Critter cans capture clean-up crews at work - University of Wisconsin - 02/04/04 Interspecies Transmission of Chronic Wasting Disease: Wisconsin Species Likely to be Exposed Department of Wildlife Ecology - CWD Page The influence of trace minerals on susceptibility to chronic wasting disease (CWD) Department of Veterinary Biomedical Sciences - Western College of Veterinary Medicine University of Saskatchewan - 30 August 2003 (pdf) Susceptibility of red deer (Cervus elaphus elaphus) to BSE Medical Research Council Molecular Basis of Barriers for Interspecies Transmissibility of Mammalian Prions Molecular Cell, Vol 14, 139-145, 9 April 2004 - full text News and Views - Understanding the diversity of prions Nature Cell Biology 6, 290 - 292 (2004) - Full Text (PDF 280k) Artificial prions created - Osherovich and colleagues have identified the amino acid sequences that allow prions to aggregate and replicate - and thereby pass through generations of cells EurekAlert! - 03/23/04 Dissection and Design of Yeast Prions PLoS Biology - Vol 2 Issue 4 April 2004 Prions: All you need is protein - Protein-only transmission of three yeast prion strains / Conformational variations in an infectious protein determine prion strain differences / Cell biology: The strain of being a prion Nature - 03/18/04 - Full Text Coexistence of CJD and Alzheimer's disease: An autopsy case showing typical clinical features of CJD Neuropathology - Volume 24 Issue 1 Page 46 - March 2004 Re: Identification of a second bovine amyloidotic spongiform encephalopathy: Molecular similarities with sporadic Creutzfeldt–Jakob disease (FULL TEXT) Terry S. Singeltary Sr. - 03/01/04 Identification of a second bovine amyloidotic spongiform encephalopathy: Molecular similarities with sporadic Creutzfeldt-Jakob disease Proc. Natl. Acad. Sci. USA, 10.1073 - Full Text RI characteristics of sporadic CJD with valine homozygosity at codon 129 of the prion protein gene and PrPSc type 2 in Japan Terry S. Singeltary Sr. - 02/13/04 Enhanced detection and retrograde axonal transport of PrPc in peripheral nerve Journal of Neurochemistry, Vol. 88, No. 1, 2004 155-160 Two Different Scrapie Prions Isolated in Japanese Sheep Flocks Microbiology and Immunology - Vol. 47 (2003) , No. 11 pp.871-876 - full text (pdf) Undesirable evolutionary consequences of trophy hunting Nature 426, 655 - 658 (11 December 2003) Critter cans capture clean-up crews at work - University of Wisconsin - 02/04/04 Interspecies Transmission of Chronic Wasting Disease: Wisconsin Species Likely to be Exposed Department of Wildlife Ecology - CWD Page Commentary: vCJD tissue distribution and transmission by transfusion--a worst-case scenario coming true? Adriano Aguzzi, Markus Glatzel Lancet 2004; 363: 411-12 Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion Lancet 2004; 363: 417-21 Tissue distribution of bovine spongiform encephalopathy agent in primates after intravenous or oral infection Lancet 2004; 363: 422-28 Caution over prion therapy - Study reveals antibodies can kill brain cells Nature - 01/30/04 OIE Scientific and Technical Review, Vol 11 (2) June 1992 Sub Acute Spongiform Encephalopathies in Animals (CWD???) Terry S. Singeltary Sr. - 01/29/04 Deer and CWD-related abstracts from the 64th Midwest Fish and Wildlife Conference - December 7-10, 2003 The Conference Managers CWD SYPMPOSIUM PROGRAM AND ABSTRACTS -- Occurrence of Creutzfeldt-Jakob Disease in Colorado and Wyoming Terry S. Singeltary Sr. - 12/06/03 Critique of CWD models Wildlife Society Bulletin 2003, 31(3) Occupational risk factors for the sporadic form of Creutzfeldt-Jakob disease Terry S. Singeltary Sr. - 11/29/03 - (full text) Mandatory deer testing may change while scientists predict CWD wiping out portions of U.S. wild deer populations Terry S. Singeltary Sr. - 11/19/03 - Advancing Prion Science: Guidance for the National Prion Research Program (2003) - National Academies Press Humanized Knock-In Mice Expressing Chimeric Prion Protein Showed Varied Susceptibility to Different Human Prions American Journal of Pathology. 2003;163:2585-2593 Academy calls for improved tests to beat prion disease - Diagnostic tests for prion diseases need a "quantum leap" in sensitivity if they are to help prevent future outbreaks, says a report from the US National Academy of Sciences Nature 426, 216 - 20 November 2003 Aguzzi warns of CWD danger - Speaking at the Days of Molecular Medicine conference in La Jolla in March, prion expert Adriano Aguzzi issued a strong warning against underestimating this form of TSE Terry S. Singeltary Sr. - 11/19/03 Abundant PrP(CWD) in tonsil from mule deer with preclinical CWD Journal of Veterinary Diagnostic Investigation. 2003 Jul;15(4):320-3 Journal Review: A Critique of CWD Models - Chronic Wasting Disease in Deer & Elk: a critique of current models and their application. Citizens Against Irrational Deer Slaughter - Wildlife Society Bulletin Experimental Transmission of Abnormal Prion Protein (PrPsc) in the Small Intestinal Epithelial Cells of Neonatal Mice Veterinary Pathology 40:723-727 (2003) Quantative understanding of transmissable spongiform encephalopathies such as BSE and CJD Terry S. Singeltary Sr. - 11/11/03 Extraneural Pathologic Prion Protein in Sporadic Creutzfeldt–Jakob Disease The New England Journal of Medicine - Volume 349:1812-1820 Number 19 - full text Natural Rubber, Latex Gloves, Condoms and TSEs aka MAD COW DISEASE Terry S. Singeltary Sr. - 11/06/03 Gene tweak halts mad cow disease - Toxic by-product, not rogue proteins, may cause fatal brain wasting Nature - 10/31/03 - Prion researcher awarded - The Scientist - 10/30/03 Copper and zinc cause delivery of the prion protein from the plasma membrane to a subset of early endosomes and the Golgi Journal of Neurochemistry, Vol. 87, No. 2, 2003 353-363 Prion diseases: A nucleic-acid accomplice? Nature 425, 673 - 674 (16 October 2003) RNA molecules stimulate prion protein conversion Nature 425, 717 - 720 (16 October 2003) - Dartmouth study - EurekAlert - 10/15/03 Routine tests reveal unknown strains of BSE prions Nature 425, 648 (16 October 2003) New test may help diagnose CJD - Host RNA boosts production of diseased prions Nature - 10/16/03 Research Requirements Document (TSE) Terry S Singeltary Sr. - 10/09/03 New Inhibitors of Scrapie-Associated Prion Protein Formation in a Library of 2,000 Drugs and Natural Products Journal of Virology, October 2003, p. 10288-10294, Vol. 77, No. 19 Diagnosing Variant Creutzfeldt-Jakob Disease with the Pulvinar Sign: MR Imaging Findings in 86 Neuropathologically Confirmed Cases American Journal of Neuroradiology 24:1560-1569, September 2003 PrP^CWD in the myenteric plexus, vagosympathetic trunk and endocrine glands of deer with chronic wasting disease Journal of General Virology (2001), 82, 2327-2334 Chronic wasting disease spreads with ease - Decades of culling and containment may be needed. Nature Science Update - 9/4/03 Prion disease: Horizontal prion transmission in mule deer - The gathering of deer during winter may foster the spread of chronic wasting disease. Nature 425, 35 - 36 (04 September 2003) - Full text Experimental inoculation of scrapie and chronic wasting disease agents in raccoons {Procyon lotor} - The Veterinary Record. July 26. 2003 Terry S Singeltary Sr. - 9/1/03 Generation of prion transmission barriers by mutational control of amyloid conformations Nature 424, 948 - 951 (21 August 2003) Tipping the Balance of Prion Infectivity AScribe Newswire - 8/20/03 CWD & RACCOONS and "new" atypical type, Nor98 Scrapie strain Mad Cow Disease discussion board with Terry S. Singeltary Sr. - 8/18/03 A novel generation of heparan sulfate mimetics for the treatment of prion diseases Journal of General Virology - 2003;84 2595-2603 Tracking spongiform encephalopathies in North America The Lancet - Volume 3, Number 8 01 August 2003 and at Terry S. Singeltary's site Chronic Wasting Disease in Deer and Elk: Scientific Facts and Findings Journal of Veterinary Medical Science Vol. 65 (2003) , No. 7 July - Full text PDF Evaluation of Quinacrine Treatment for Prion Diseases Journal of Virology, August 2003, p. 8462-8469, Vol. 77, No. 15 (abstact) Researches find CWD more prevalent in older bucks - Disease is also not uniformly distributed within infected area. ...the intensive harvest zone last year show a core area in Dane and Iowa counties where the disease was found in about 7 percent of the deer Wisconsin Department of Natural Resources - 7/1/03 Subclinical Prion Disease Induced by Oral Inoculation Journal of Virology, July 2003, p. 7991-7998, Vol. 77, No. 14 (abstact) Prion diseases: infectious and lethal doses following oral challenge J Gen Virol 84 (2003), 1927-1929; DOI 10.1099/vir.0.19037-0 (abstract) Ultra-high-pressure inactivation of prion infectivity in processed meat: A practical method to prevent human infection Proc. Natl. Acad. Sci. USA, 10.1073/pnas.1031826100 (abstract) Antibodies cripple prions Nature - 3/6/03 RE-Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States - by Terry S. Singeltary Neurology 2003 - Post-Publication Peer Reviews - more from Terry... Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States Neurology 2003;60:176-181 abstract - full text Opinion on Chronic Wasting Disease and tissues that might carry a risk for human and animal feed chains Scientific Steering Committee - Meeting of 6-7 March 2003 (pdf file) Ultra-high-pressure inactivation of prion infectivity in processed meat: A practical method to prevent human infection Proc. Natl. Acad. Sci. USA, 10.1073/pnas.1031826100 (abstract) Analysis of unusual accumulation of Creutzfeldt-Jakob disease cases in Orava and Liptov regions (northern Slovak focus) 1983-2000. - "The majority of CJD patients admitted consuming sheep brain" Cent Eur J Public Health 2003 Mar;11(1):19-22 - more... Disease-associated PrP in the enteric nervous system of scrapie-affected Suffolk sheep J Gen Virol 2003 84: 1327-1338 Distinct profiles of PrPd immunoreactivity in the brain of scrapie- and BSE-infected sheep: implications for differential cell targeting and PrP processing J Gen Virol 2003 84: 1339-1350 Widespread PrPSc accumulation in muscles of hamsters orally infected with scrapie EMBO reports AOP doi:10.1038/sj.embor.embor827 11 April 2003 Balancing Selection at the Prion Protein Gene Consistent with Prehistoric Kurulike Epidemics Science - 4/10/03 - Science Supporting Online Material (pdf) Soluble Dimeric Prion Protein Binds PrPSc In Vivo and Antagonizes Prion Disease Cell, Vol 113, 49-60, April 2003 Prion principle proved - Captured protein couple may help treat brain disease. Nature - 4/4/03 Prions—they really do get up your nose The Lancet Infectious Diseases - Vol 3, Num 4 (registration required) or here Studies of the transmissibility of the agent of bovine spongiform encephalopathy to pigs Journal of General Virology 84 (2003), 1021-1031 Preliminary Observations on the Experimental Transmission of Scrapie to Elk (Cervus elaphus nelsoni) by Intracerebral Inoculation Veterinary Pathology 40:81-85 (2003) Accumulation of Pathogenic Prion Protein (PrPSc) in Nervous and Lymphoid Tissues of Sheep with Subclinical Scrapie Veterinary Pathology 40:164-174 (2003) Detection of Pathologic Prion Protein in the Olfactory Epithelium in Sporadic Creutzfeldt–Jakob Disease The New England Journal of Medicine - Vol 348:711-719 Feb 20, 2003 Num 8 Prion pathogenesis in the absence of Toll-like receptor signalling EMBO reports 4, 2, 195–199 (2003) (abstract) Prions get fishy - Primitive prion hints at origins of brain disease Nature - 1/31/03 Prion Disease May Be Caused By Buildup Of Cellular Trash, Say Stanford Researchers Science Daily - 2/3/03 BSE – a wolf in sheep's clothing? Trends in Microbiology - Vol. 11, No. 1, January 2003 (registration required) Prion Disease Treatment's Early Promise Unravels Science - 2003 299(5604): p. 191-192 Anti-prion antibodies for prophylaxis following prion exposure in mice. Neuroscience Letters 2003 Jan 23;336(3):185-7 Complete Freund's adjuvant immunization prolongs survival in experimental prion disease in mice. Journal of Neuroscience Research Vol. 71, Issue 2, 2003. Pages: 286-290 Rapid Prion Neuroinvasion following Tongue Infection Journal of Virology, January 2003, p. 583-591, Vol. 77, No. 1 vCJD complacency—cause for alarm? The Lancet Neurology - Vol 2, Num 1, 01 January 2003 (registration required) or here White-tailed deer impact on the vegetation dynamics of a northern hardwood forest Ecological Applications: Vol. 13, No. 1, pp. 98–118 (absract) - Study sees link between deer, forest problems - Washington Observer Reporter (Pennsylvania) - 1/7/03 A Genetic Approach to the Problem of Chronic Wasting Disease in Wisconsin Wisconsin Medical Journal - Fall 2002 Volume 1 No. 2 - Full Text PDF Comparison of Abnormal Prion Protein Glycoform Patterns from TSE Agent-Infected Deer, Elk, Sheep, and Cattle Journal of Virology, Dec. 2002, p. 12365-12368 Mad deer The North American version of prion disease European Molecular Biology Organization - vol. 3, no. 12, pp 1117-1119, 2002 BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein The EMBO Journal, Vol. 21, No. 23 pp. 6358-6366, 2002 - Full Text Preclinical diagnosis of CWD in captive mule deer and white-tailed deer using tonsillar biopsy Journal of General Virology (2002), 83, 2629 2634 BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein The EMBO Journal, Vol. 21, No. 23 pp. 6358-6366, 2002 Subclinical Scrapie Infection in a Resistant Species: Persistence, Replication, and Adaptation of Infectivity during Four Passages. J Infect Dis 2002 Dec 1;186 Suppl 2:S166-70 Creutzfeldt–Jakob disease in Australia 1970–1999 Neurology 2002;59:1365-1371 Together PCs forecast fold - Many computers make light work of predicting protein shape Nature - 10/21/02 - folding@home website CWD and neurological disease cluster link investigated - "Of one group of 75 people who regularly attended these annual meals in the US midwest since the late 1970s, 43 have been contacted and interviewed" The Lancet Neurology - Volume 2, Number 11 - 11/1/02 (registation required) or here Mutant prions to the rescue The Lancet Neurology - Volume 2, Number 11 - 11/1/02 (registation required) or here Comparison of Abnormal Prion Protein Glycoform Patterns from Transmissible Spongiform Encephalopathy Agent-Infected Deer, Elk, Sheep, and Cattle Journal of Virology, December 2002, p. 12365-12368, Vol. 76, No. 23 A Case of Chronic Wasting Disease in an Elk Imported to Korea from Canada Journal of Veterinary Medical Science - Vol. 64, No. 9 pp.855-858 - full PDF Bovine spongiform encephalopathy, chronic wasting disease, scrapie, and the threat to humans from prion disease epizootics - "Reliable experimental models for determining the resistance of humans to animal prion diseases do not yet exist." Curr Neurol Neurosci Rep 2002 Nov;2(6):488-95 Transmission of prion diseases by blood transfusion Journal of General Virology (2002), 83, 2897-2905 - Full text pdf Scrapie epidemic in a fully PrP-genotyped sheep flock Journal of General Virology (2002), 83, 2907-2914. Dominant-negative inhibition of prion replication in transgenic mice Proceedings of the National Academy of Sciences - 10.1073/pnas.182425299 Prion transmission in blood and urine: what are the implications for recombinant and urinary-derived gonadotrophins? Hum Reprod 2002 Oct;17(10):2501-8 Prions, BSE and food. Int J Food Microbiol 2002 Sep 15;78(1-2):181-9 Distribution of protease-resistant prion protein and spongiform encephalopathy in free-ranging mule deer (Odocoileus hemionus) with chronic wasting disease. Vet Pathol 2002 Sep;39(5):546-56 Dominant-negative inhibition of prion replication in transgenic mice Proceedings of the National Academy of Sciences - 10.1073/pnas.182425299 Preclinical diagnosis of chronic wasting disease in captive mule deer (Odocoileus hemionus) and white-tailed deer (Odocoileus virginianus) using tonsillar biopsy Journal of General Virology - October 2002; Volume 83, 2629-2634 PrP^CWD lymphoid cell targets in early and advanced chronic wasting disease of mule deer Journal of General Virology - October 2002; Volume 83, 2617-2628 Abundant PrP(CWD) in tonsil from mule deer with preclinical CWD Journal of Veterinary Diagnostic Investigation. 2003 Jul;15(4):320-3 Creutzfeldt-Jakob disease in unusually young patients who consumed venison Archives of Neurology - October, 2001 Prions in skeletal muscle - "That some muscles are intrinsically capable of accumulating substantial titers of prions is of particular concern." Proceedings of The National Academy of Sciences - 3/12/02 Worrying rise in Swiss CJD - "Sporadic CJD (sCJD) is evenly distributed worldwide with an incidence of around one in a million people. However, this rate doubled in 2001..." The Lancet - 7/13/02 (registration required) or at Mad Cowboy Incidence of Creutzfeldt-Jakob disease in Switzerland The Lancet - 7/13/02 (registration required) or at Mad Cowboy (no graphics) Evidence of a molecular barrier limiting susceptibility of humans, cattle and sheep to chronic wasting disease The EMBO Journal, Vol. 19, No. 17 pp. 4425-4430, 2000 Transmission of BSE by blood transfusion in sheep - "...by transfusion with whole blood taken from another sheep during the symptom-free phase of an experimental BSE infection. The Lancet - Abstract or at www.mad-cow.org Migrating intestinal dendritic cells transport PrP^Sc from the gut Journal of General Virology - January, 2002 - Abstract Preliminary findings on the experimental transmission of chronic wasting disease agent of mule deer to cattle National Animal Disease Center, ARS, USDA, Ames, IA Experimental infection of cattle with the agents of transmissible mink encephalopathy and scrapie. USDA-ARS Animal Disease Research Unit, Washington State University Epidemiological and experimental studies on a new incident of transmissible mink encephalopathy. - RF Marsh, RA Bessen, S Lehmann and GR Hartsough Department of Veterinary Science, University of Wisconsin - Abstract Oral transmission and early lymphoid tropism of chronic wasting disease PrP^res in mule deer fawns (Odocoileus hemionus ) Abstract Full Text Distribution of the prion protein in sheep terminally affected with BSE following experimental oral transmission Journal of General Virology - Abstract The host range of chronic wasting disease is altered on passage in ferrets. - Bartz JC, Marsh RF, McKenzie DI, Aiken JM. Department of Animal Health and Biomedical Sciences, University of Wisconsin Hypotheses concerning the origin, infective agent, transport, and pathology of TSEs http://www.priondata.org/data/A_hypoth.html Spiroplasma & Transmissible Spongiform Encephalopathies - "Bastian insists that the infection-related protein that most researchers refer to as a "prion" is produced by the host in response to the infection and is not the causative agent. Prions are thought to be self-replicating proteins." http://sparc.airtime.co.uk/bse//gehrman.htm CJD Diagnostic & Research Center - "About 20 million dollars is directed to CJD research each year but the bulk goes to one laboratory (Prusiner's laboratory received 14 million last year according to Nature)." www.cjddiagnosticcenter.com Spiroplasma may cause Creutzfeldt-Jakob Disease - An interview with a leading expert in infectious diseases - Frank O. Bastian, MD Infectious Disease News - June 1996 New Evidence of Sub-Clinical Prion Infection: Important Research Findings Relevant to CJD and BSE - "we should not assume that just because one species appears resistant to a strain of prions they have been exposed to, that they do not silently carry the infection." Medical Research Council - 8/28/00 The Use of Antioxidants in Transmissible Spongiform Encephalopathies: A Case Report - "During the course of her hospitalization, the family administered a mixture of antioxidants including NADH, vitamin E (mixed tocopherols), alpha lipoic acid, multivitamin and a fresh fruit and vegetable puree, which was taken over several days. After this administration, the patient became more responsive and began to speak in appropriate although short sentences. Journal of the American College of Nutrition, Vol. 21, No. 1, 22-25 (2002) Spatial and Temporal Dynamics of Prion Disease in Wildlife: Responses to Changing Land Use Colorado State University The Whole Brain Atlas http://www.med.harvard.edu/ All the Virology on the WWW http://www.virology.net/garryfavweb.html The Big Picture Book of Viruses: Retroviridae - Check out the diseases in this family of viruses including visna/maedi virus (scrapie) http://www.virology.net/Big_Virology/BVretro.html National Animal Disease Center - Ames, Iowa http://www.nadc.ars.usda.gov/ Bovine Spongiform Encephalopathy (BSE) and Other Animal Related Transmissible Spongiform Encephalopathies - very long Bibliography of Selected Articles, 1995 - 2002 United States Department of Agriculture, Agricultural Research Service, National Agricultural Library, Animal Welfare Information Center 5 die of Creutzfeldt-Jakob Disease in U.S. from eating Squirrel - CJD connection was ridiculed so extensively that Drs. Berger and Weisman have had trouble acquiring additional funding to test their hypothesis. The Lancet - Vol 350 - 8/30/97 PDF file (must register)or here and in Field & Stream. The Common Cause Medical Research Foundation http://www.carolsweb.net/ccf/index.htm Pathogenic mycoplasma - "In addition to AIDS, Mycoplasma fermentans incognitus has been implicated in a number of other Disease states including Chronic Fatigue Syndrome, Wegener's Disease, Sarcoidosis, respiratory distress syndrome, Kikuchi's disease, autoimmune diseases such as Collagen Vascular Disease and Lupus, and chronic debilitating diseases such as Alzheimer's Disease. M. fermentans incognitus may be either a causative agent of these diseases or a key co-factor in these diseases." U.S. Patent # 5,242,820 Detection of transmissible spongiform encephalopathies - "...method of detecting transmissible spongiform encephalopathies (TSE) which utilizes a nested polymerase chain reaction for sensitive and specific detection of spiroplasma 16S rDNA in TSE." U.S. Patent # 6,033,858 Contact Information email - comments@maddeer.org Copyright © 2002 maddeer.org